My sister and I had a SLOB (Spontaneous Lighthearted Optimistic Beloved) Convention in Portland, Oregon and invited Marla Cilley, the Flylady to speak. Her words are so wise and so worth heeding. Watch this video and see if you see yourself in her talk.
If you're serious about simplifying your life, I recommend The Joy of Being Disorganized.
It not only gives you the way to declutter, room-by-room, but it gives a simplified version of the Sidetracked Home Executives 3x5 card system for organizing your home and family.